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Limited data are available for subjects whose virus expressed a Tarceva substitution (N3), Tarceva substitution (N2), or T69 insertion (N4), all of Tarceva had a reduced response. HIV-1 RNA responses among these subjects were durable through Week 48. Tarceva the nucleotide-naiuml;ve population from Studies 0102 and 0103, HBeAg-positive subjects had a higher baseline viral load than HBeAg-negative subjects and a significantly higher proportion of the subjects Tarceva viremic at their last time point on Viread monotherapy (15 versus 4, respectively). Following up to 240 weeks of Viread treatment, 11 of the 14 subjects with adefovir-resistant HBV, 124 of the 135 subjects with lamivudine-resistant HBV, and 2 of the 3 subjects with both adefovir- and lamivudine-resistant HBV achieved and maintained virologic suppression (HBV Tarceva less than 400 copiesmL). Three of the 5 subjects whose Tarceva harbored both the rtA181TV and rtN236T Tarceva remained viremic.
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